PDRN(Polydeoxyribonucleotide)

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Origin of PDRN It is extracted from wild salmon sperm which is almost match up to human DNA

Production planning

StartFragmentPDRN(Poly Deoxy Ribo Nucleotide)

Origin of PDRN It is extracted from wild salmon sperm which is almost match up to human DNA

The content of nucleic acids as compared to the other material over 1,000 times.

Mechanism HP Cell is manufactured for promoting skin health through cell regeneration. HP Cell is made of excellent materials which is safe proved and as marvelous efficacy to stimulate differentiation of fibroblast , and produce of collagen & elastin and also to increase anti-inflammation factor(cytokines ), blood vessel creation factor(VEGF) and other growth factors.

Action mechanism It stimulating adenosine A2 receptor to accelerating anti-inflammatory cytokines / growth factor/ VEGF. Through these factors plays a differentiation / growth and Collagen / ECM generation promotion / capillary vascular tissue through differentiation of fibroblasts.

Safey of PDRN

Examine of toxicity as per concentration of HP DNA. Even though the concentration of PDRN is increased, Toxicity is not detected, survival rate and cell division is still increased.

Figure 1. Cytotoxcity - cell viability (% control) Figure 2. Cell proliferation assay (% control) BR Pharm-Choongang Univ. Dept. of Dermatol.

Efficacy of PDRN By experiment on animal(rat), observed that the speed of recovery of injury has been increased HP DNA, Histologically, skin and connective tissue is recovered quickly with HP DNA treatment.

Figure 3. Wound closure - DSLR, PRIMOSLTTE

Figure 4. Histology (Masson's - Trichrome, van Gieson stain) : Microscope (OLYMPUS IX71, Japan) Red: keratin &, muscle fiber, Blue: collagen & bone, Pink cytoplasm BR Pharm-Choongang Univ. Dept. of Dermatol.

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